Occludin Antikörper (AA 54-270)

Produktnummer ABIN7875650

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Occludin in WB, ELISA, FACS, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Occludin Antikörper (AA 54-270) (ABIN7875650)

Target: Occludin (OCLN)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Occludin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Occludin Antikörper

Bindungsspezifität: AA 54-270

Verwendungszweck: OCLN Antibody / Occludin

Aufreinigung: Affinity purified

Immunogen: Recombinant human protein (amino acids H54-K270) was used as the immunogen for the OCLN antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the OCLN antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the OCLN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Occludin

Target: Occludin (OCLN)

Andere Bezeichnung: OCLN

Hintergrund: Occludin is an integral membrane protein that is located at tight junctions. It is a member of a family of proteins containing the highly conserved Marvel domain, which contains 4 transmembrane-helix regions. This gene is mapped to 5q13.2. Occludin regulates TGF-beta receptor type I localization for efficient TGF-beta-dependent dissolution of tight junctions during epithelial-mesenchymal transitions. Human Occludin is an essential hepatitis C virus (HCV) cell entry factor that is able to render murine cells infectable with HCV glycoproteins. It has been found that occludin is involved in cell migration and functions to recruit active PI3 kinase to the leading edge, resulting in RAC1 activation and formation of lamellipodia.

UniProt: Q16625

Pathways: Cell-Cell Junction Organization, Hepatitis C