HAAO Antikörper (AA 52-286)

Produktnummer ABIN7875557

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HAAO in WB, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für HAAO Antikörper (AA 52-286) (ABIN7875557)

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAAO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-HAAO Antikörper

Bindungsspezifität: AA 52-286

Verwendungszweck: HAAO Antibody / 3-hydroxyanthranilate 3, 4-dioxygenase / 3HAO

Aufreinigung: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids E52-G286) was used as the immunogen for the HAAO antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the HAAO antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the HAAO Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu HAAO

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Andere Bezeichnung: HAAO

Hintergrund: 3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) is an enzyme encoded by the HAAO gene. 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

UniProt: P46952