SOX11 Antikörper (AA 50-200)

Produktnummer ABIN7875330

Der Maus Monoklonal anti-SOX11 Antikörper wird verwendet zum Nachweis von SOX11 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für SOX11 Antikörper (AA 50-200) (ABIN7875330)

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOX11 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: SOX11-7236

Produktdetails anti-SOX11 Antikörper

Bindungsspezifität: AA 50-200

Verwendungszweck: SOX11 Antibody

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 50-200 was used as the immunogen for the SOX11 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SOX11 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SOX11 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu SOX11

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Andere Bezeichnung: SOX11

Hintergrund: Recognizes a protein of ~47 kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5 % to 10 % of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5 %-10 % of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.

UniProt: P35716

Pathways: Tube Formation