SNX25 Antikörper (AA 48-584)

Produktnummer ABIN7875212

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SNX25 in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für SNX25 Antikörper (AA 48-584) (ABIN7875212)

Target: SNX25 (Sorting Nexin 25 (SNX25))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNX25 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-SNX25 Antikörper

Bindungsspezifität: AA 48-584

Verwendungszweck: SNX25 Antibody / Sorting nexin 25

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SNX25 recombinant protein (Position: H48-K584) was used as the immunogen for the SNX25 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SNX25 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SNX25 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SNX25

Target: SNX25 (Sorting Nexin 25 (SNX25))

Andere Bezeichnung: SNX25

Hintergrund: SNX25 antibody detects Sorting nexin-25, a member of the sorting nexin family involved in endosomal trafficking, receptor recycling, and membrane remodeling. SNX25 plays critical roles in signal transduction and protein turnover by directing cargo sorting within endosomes. The SNX25 antibody is widely used in cell biology, immunology, and receptor signaling studies to explore intracellular trafficking and degradation pathways.

SNX25 is encoded by the SNX25 gene located on human chromosome 4q24. The protein is approximately 580 amino acids long and contains a conserved phox homology (PX) domain that binds phosphatidylinositol-3-phosphate and a Bin/Amphiphysin/Rvs (BAR) domain that senses and induces membrane curvature. These structural domains enable SNX25 to participate in tubular endosome formation and cargo retrieval to the Golgi or plasma membrane.

The SNX25 antibody detects a 67 kilodalton band by western blot and shows cytoplasmic and vesicular staining by immunofluorescence. SNX25 interacts with transforming growth factor beta receptor complexes and promotes their endocytic degradation, acting as a negative regulator of transforming growth factor beta signaling. By controlling receptor turnover, SNX25 influences cellular proliferation, differentiation, and immune tolerance.

SNX25 also regulates Toll-like receptor trafficking in macrophages, affecting cytokine production and innate immune responses. In neurons, SNX25 participates in the endosomal sorting of synaptic receptors and contributes to synaptic plasticity. Its expression is dynamically regulated by inflammatory cues and cellular stress, linking endosomal remodeling to signaling adaptation.

Aberrant expression of SNX25 has been associated with cancer progression and immune dysregulation. Downregulation enhances transforming growth factor beta activity, promoting fibrosis and epithelial-mesenchymal transition, while overexpression suppresses pro-inflammatory signaling. NSJ Bioreagents provides a validated SNX25 antibody optimized for western blot and flow cytometry, supporting detailed studies of receptor sorting, endosomal dynamics, and signaling modulation.

UniProt: Q9H3E2

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling