SCARB2 Antikörper (AA 48-357)

Produktnummer ABIN7875206

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SCARB2 in WB, ELISA, IHC (p), FACS und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SCARB2 Antikörper (AA 48-357) (ABIN7875206)

Target: SCARB2 (Scavenger Receptor Class B, Member 2 (SCARB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SCARB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-SCARB2 Antikörper

Bindungsspezifität: AA 48-357

Verwendungszweck: SR-BII Antibody / SCARB2 / LIMPII

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E48-H357) was used as the immunogen for the SR-BII antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SR-BII antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SR-BII antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SCARB2

Target: SCARB2 (Scavenger Receptor Class B, Member 2 (SCARB2))

Andere Bezeichnung: SR-BII

Hintergrund: Lysosomal integral membrane protein 2 (LIMP-2), also called Scavenger receptor class B member 2, is a protein that in humans is encoded by the SCARB2 gene. The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt: Q14108