IDE Antikörper (AA 464-735)

Produktnummer ABIN7875138

Der Kaninchen Polyklonal anti-IDE Antikörper wird verwendet zum Nachweis von IDE in Proben von Zebrafisch (Danio rerio). Er wurde validiert für WB und IHC (p).

Kurzübersicht für IDE Antikörper (AA 464-735) (ABIN7875138)

Target: IDE (Insulin-Degrading Enzyme (IDE))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IDE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-IDE Antikörper

Bindungsspezifität: AA 464-735

Verwendungszweck: Zebrafish Ide Antibody / Insulin degrading enzyme

Aufreinigung: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish Ide recombinant protein (amino acids F464-K735) was used as the immunogen for the Zebrafish Ide antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Ide antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Ide antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu IDE

Target: IDE (Insulin-Degrading Enzyme (IDE))

Andere Bezeichnung: Ide

Hintergrund: Insulin-degrading enzyme, also known as IDE, is a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signaling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causative for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Pathways: SARS-CoV-2 Protein Interaktom