RNF34 Antikörper (AA 46-372)

Produktnummer ABIN7875119

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RNF34 in WB, ELISA, IHC (p), IF und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für RNF34 Antikörper (AA 46-372) (ABIN7875119)

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF34 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-RNF34 Antikörper

Bindungsspezifität: AA 46-372

Verwendungszweck: RNF34 Antibody / hRFI / CARP-1

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E46-S372) was used as the immunogen for the RNF34 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the RNF34 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the RNF34 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu RNF34

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Andere Bezeichnung: RNF34

Hintergrund: E3 ubiquitin-protein ligase RNF34, also called Human RING finger homologous to inhibitor of apoptosis protein (hRFI) and Caspases-8 and -10-associated RING finger protein 1 (CARP-1) is an enzyme that in humans is encoded by the RNF34 gene. The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.

UniProt: Q969K3