ChT Antikörper (AA 446-580)

Produktnummer ABIN7875049

Der Kaninchen Polyklonal anti-ChT Antikörper (ABIN7875049) detektiert spezifisch ChT in WB, FACS und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Maus, Human und Ratte.

Kurzübersicht für ChT Antikörper (AA 446-580) (ABIN7875049)

Target: ChT (High Affinity Choline Transporter (ChT))

Reaktivität: Maus, Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ChT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Produktdetails anti-ChT Antikörper

Bindungsspezifität: AA 446-580

Verwendungszweck: SLC5A7 Antibody / High affinity choline transporter 1

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R446-Q580) was used as the immunogen for the SLC5A7 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SLC5A7 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SLC5A7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ChT

Target: ChT (High Affinity Choline Transporter (ChT))

Andere Bezeichnung: SLC5A7

Hintergrund: The high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene. This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants.

UniProt: Q9GZV3