GRM2 Antikörper (AA 439-710)

Produktnummer ABIN7875001

Der Kaninchen Polyklonal anti-GRM2 Antikörper (ABIN7875001) detektiert spezifisch GRM2 in WB, ELISA, IHC (p) und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für GRM2 Antikörper (AA 439-710) (ABIN7875001)

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-GRM2 Antikörper

Bindungsspezifität: AA 439-710

Verwendungszweck: GRM2 Antibody / Metabotropic Glutamate Receptor 2

Aufreinigung: Affinity purified

Immunogen: A human recombinant protein (amino acids N439-A710) was used as the immunogen for the GRM2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GRM2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the GRM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu GRM2

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Andere Bezeichnung: GRM2

Hintergrund: Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. It is mapped to 3p21.2. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

UniProt: Q14416

Pathways: cAMP Metabolic Process, Dicarboxylic Acid Transport