DHCR7 Antikörper (AA 437-463)

Produktnummer ABIN7874996

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DHCR7 in WB, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für DHCR7 Antikörper (AA 437-463) (ABIN7874996)

Target: DHCR7 (7-Dehydrocholesterol Reductase (DHCR7))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DHCR7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DHCR7 Antikörper

Bindungsspezifität: AA 437-463

Verwendungszweck: DHCR7 Antibody / 7-dehydrocholesterol reductase

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 437-463 from the human protein was used as the immunogen for the DHCR7 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the DHCR7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the DHCR7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu DHCR7

Target: DHCR7 (7-Dehydrocholesterol Reductase (DHCR7))

Andere Bezeichnung: DHCR7

Hintergrund: This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS), a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

UniProt: Q9UBM7