Uromodulin Antikörper (AA 43-618)

Produktnummer ABIN7874973

Der Kaninchen Polyklonal anti-Uromodulin Antikörper wird verwendet zum Nachweis von Uromodulin in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC (p) und FACS.

Kurzübersicht für Uromodulin Antikörper (AA 43-618) (ABIN7874973)

Target: Uromodulin (UMOD)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Uromodulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-Uromodulin Antikörper

Bindungsspezifität: AA 43-618

Verwendungszweck: Uromodulin Antibody / UMOD

Aufreinigung: Affinity purified

Immunogen: Recombinant human protein (amino acids E43-S618) was used as the immunogen for the Uromodulin antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Uromodulin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Uromodulin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Uromodulin

Target: Uromodulin (UMOD)

Andere Bezeichnung: Uromodulin

Hintergrund: Uromodulin (UMOD), also known as Tamm-Horsfall protein (THP), is a glycoprotein that in humans is encoded by the UMOD gene. The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.

UniProt: P07911