PITPNM1 Antikörper (AA 418-831)

Produktnummer ABIN7874910

Der Kaninchen Polyklonal anti-PITPNM1 Antikörper wird verwendet zum Nachweis von PITPNM1 in Proben von Human, Ratte und Maus. Er wurde validiert für ELISA, WB und FACS.

Kurzübersicht für PITPNM1 Antikörper (AA 418-831) (ABIN7874910)

Target: PITPNM1 (Phosphatidylinositol Transfer Protein, Membrane-Associated 1 (PITPNM1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PITPNM1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-PITPNM1 Antikörper

Bindungsspezifität: AA 418-831

Verwendungszweck: PITPNM1 Antibody / Phosphatidylinositol transfer protein membrane associated 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human Nir2/PITPNM1 recombinant protein (Position: E418-R831) was used as the immunogen for the PITPNM1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PITPNM1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PITPNM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PITPNM1

Target: PITPNM1 (Phosphatidylinositol Transfer Protein, Membrane-Associated 1 (PITPNM1))

Andere Bezeichnung: PITPNM1

Hintergrund: PITPNM1 antibody detects Phosphatidylinositol transfer protein membrane associated 1, encoded by the PITPNM1 gene. Phosphatidylinositol transfer protein membrane associated 1 is a large multi-domain protein localized to membranes and involved in phosphoinositide signaling and vesicular trafficking. PITPNM1 antibody provides researchers with a reagent to study lipid metabolism, intracellular signaling, and membrane dynamics.

Phosphatidylinositol transfer protein membrane associated 1 is part of the retinal degeneration B protein family. Research using PITPNM1 antibody has shown that it binds and transfers phosphatidylinositol and phosphatidic acid between membranes. This transfer activity regulates phosphoinositide pools that are critical for vesicular transport, endocytosis, and exocytosis. By maintaining lipid composition, PITPNM1 ensures membrane identity and function.

Studies with PITPNM1 antibody have revealed that the protein localizes to the Golgi apparatus, endoplasmic reticulum, and plasma membrane. This localization supports its function in coordinating vesicular trafficking between secretory and endocytic pathways. PITPNM1 interacts with Rab and Arf proteins, integrating lipid metabolism with trafficking machinery. These findings highlight its role in cellular logistics and signaling.

Phosphatidylinositol transfer protein membrane associated 1 has been linked to neuronal biology and retinal function. Research using PITPNM1 antibody has suggested that it contributes to photoreceptor maintenance, and mutations in related family members are associated with retinal degeneration. Dysregulation of PITPNM1 expression has also been implicated in cancer, where altered lipid signaling supports proliferation and survival. This underscores the significance of PITPNM1 in both physiology and pathology.

PITPNM1 antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects expression in diverse tissues, immunohistochemistry reveals subcellular distribution in the Golgi and ER, and immunofluorescence highlights its role in vesicular trafficking. These approaches make PITPNM1 antibody a valuable tool in lipid biology and membrane trafficking research.

By supplying validated PITPNM1 antibody reagents, NSJ Bioreagents supports studies into phosphoinositide signaling, membrane dynamics, and disease. Detection of Phosphatidylinositol transfer protein membrane associated 1 provides researchers with insights into how lipid transfer proteins coordinate cellular processes.

UniProt: O00562