MYBBP1A Antikörper (AA 41-1058)

Produktnummer ABIN7874821

Der Kaninchen Polyklonal anti-MYBBP1A Antikörper (ABIN7874821) detektiert spezifisch MYBBP1A in WB, ELISA, IF, ICC und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für MYBBP1A Antikörper (AA 41-1058) (ABIN7874821)

Target: MYBBP1A (Myb-Binding Protein 1A (MYBBP1A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYBBP1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Produktdetails anti-MYBBP1A Antikörper

Bindungsspezifität: AA 41-1058

Verwendungszweck: MYBBP1A Antibody / Myb-binding protein 1A

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human MYBBP1A recombinant protein (Position: D41-Q1058) was used as the immunogen for the MYBBP1A antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MYBBP1A antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the MYBBP1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MYBBP1A

Target: MYBBP1A (Myb-Binding Protein 1A (MYBBP1A))

Andere Bezeichnung: MYBBP1A

Hintergrund: MYBBP1A antibody detects Myb-binding protein 1A, encoded by the MYBBP1A gene. Myb-binding protein 1A is a nucleolar protein that participates in transcriptional regulation, ribosome biogenesis, and stress signaling. MYBBP1A antibody provides researchers with a versatile reagent for studying nuclear protein interactions, tumor suppression, and stress-responsive transcriptional programs.

Myb-binding protein 1A was first identified as a factor that interacts with the transcription factor c-Myb. Research using MYBBP1A antibody has shown that it acts as a transcriptional regulator by modulating Myb-dependent genes and other transcriptional pathways. It functions as a co-repressor or co-activator depending on cellular context, influencing cell proliferation and differentiation.

Studies with MYBBP1A antibody have revealed that the protein localizes to the nucleolus under basal conditions but translocates to the nucleoplasm upon cellular stress. This dynamic distribution links ribosome biogenesis to stress-responsive transcriptional regulation. MYBBP1A influences ribosomal RNA transcription, p53 activation, and chromatin remodeling, emphasizing its multifunctional nature.

Dysregulation of Myb-binding protein 1A has been linked to cancer and stress-related pathology. Research using MYBBP1A antibody has shown that reduced expression contributes to tumorigenesis by impairing p53-mediated responses. Conversely, overexpression can suppress tumor growth by activating apoptosis pathways. This dual role highlights its complex involvement in cancer biology.

Beyond cancer, MYBBP1A participates in metabolic regulation and cellular senescence. Research using MYBBP1A antibody has suggested roles in controlling NF-kB signaling, mitochondrial stress responses, and transcription of metabolic genes. These findings underscore its integration of stress responses with transcriptional networks.

MYBBP1A antibody is widely applied in western blotting, immunohistochemistry, and chromatin immunoprecipitation. Western blotting quantifies protein levels, immunohistochemistry demonstrates nucleolar localization, and chromatin immunoprecipitation identifies transcriptional binding partners. These applications make MYBBP1A antibody indispensable in nuclear biology and cancer research.

By providing validated MYBBP1A antibody reagents, NSJ Bioreagents supports studies into transcriptional regulation, stress signaling, and tumor suppression. Detection of Myb-binding protein 1A provides researchers with insight into how nucleolar proteins integrate ribosome biogenesis and stress responses.

UniProt: Q9BQG0