MX1 Antikörper (AA 400-592)

Produktnummer ABIN7874739

Der Maus Monoklonal anti-MX1 Antikörper wird verwendet zum Nachweis von MX1 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für MX1 Antikörper (AA 400-592) (ABIN7874739)

Target: MX1 (Myxovirus Resistance Protein 1 (MX1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MX1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: MX1-7527

Produktdetails anti-MX1 Antikörper

Bindungsspezifität: AA 400-592

Verwendungszweck: MX1 Antibody / Myxovirus resistance protein 1 / MxA (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 400-592) from the human protein was used as the immunogen for the MX1 antibody.

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MX1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the MX1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu MX1

Target: MX1 (Myxovirus Resistance Protein 1 (MX1))

Andere Bezeichnung: MX1

Hintergrund: The Dynamin family of microtubule-associated proteins function as GTPases that are involved in microtubule bundling and endocytosis. In mice, Mx2 (myxovirus resistance protein 2) and Mx1 (myxovirus resistance protein 1) are members of the Dynamin family that are involved in the immune response to viral infections. Localized to the cytoplasm, Mx2 contains one GED domain and is expressed in response to viral infection or treatment by IFN-a/IFN-b. Once expression is induced, Mx2 accumulates in the cytoplasm and inhibits the replication of vesicular stomatitis virus (VSV), thereby conferring resistance to VSV infection. Unlike Mx2, Mx1 is localized to the nucleus where, upon induction by IFN-a/IFN-b, it provides selective resistance to infection by the highly lethal H5N1 influenza virus. In humans, MxA and MxB function in a similar manner to Mx1 and Mx2, conferring resistance to specific target viruses. Mx3 is a rat-specific member of the myxovirus resistance protein family.

UniProt: P20591