GBP1 Antikörper (AA 400-592)

Produktnummer ABIN7874731

Der Maus Monoklonal anti-GBP1 Antikörper (Klon GBP1-7618) (ABIN7874731) detektiert spezifisch GBP1 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für GBP1 Antikörper (AA 400-592) (ABIN7874731)

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GBP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: GBP1-7618

Produktdetails anti-GBP1 Antikörper

Bindungsspezifität: AA 400-592

Verwendungszweck: GBP1 Antibody / Guanylate binding protein 1 (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 400-592) from the human protein was used as the immunogen for the GBP1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GBP1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the GBP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu GBP1

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Andere Bezeichnung: GBP1

Hintergrund: GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage steps, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-g during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.

UniProt: P32455

Pathways: Cellular Response to Molecule of Bacterial Origin