Stonin 2 (STON2) (AA 4-855) Antikörper

Produktnummer ABIN7874686

Der Kaninchen Polyklonal anti-Stonin 2 Antikörper (ABIN7874686) detektiert spezifisch Stonin 2 in WB, ELISA, FACS, IF und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Stonin 2 (STON2) (AA 4-855) Antikörper (ABIN7874686)

Target: Stonin 2 (STON2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails

Bindungsspezifität: AA 4-855

Verwendungszweck: STON2 Antibody / Stonin 2

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids L4-K855 from the human protein were used as the immunogen for the STON2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the STON2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the STON2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Antigendetails

Target: Stonin 2 (STON2)

Andere Bezeichnung: STON2

Hintergrund: STON2 (Stonin 2) is a member of the stonin protein family, which plays an important role in clathrin-mediated endocytosis. It functions as an adaptor protein that interacts with components of the endocytic machinery, including clathrin and adaptor protein complexes, to facilitate the internalization of synaptic vesicle proteins and receptors. By regulating vesicle recycling, STON2 contributes to synaptic transmission and receptor turnover. Researchers often use a STON2 antibody to study endocytosis, neuronal signaling, and membrane trafficking.

STON2 contains multiple protein interaction motifs, including proline-rich domains and endocytic sorting signals, which allow it to engage with dynamin and AP-2 complex subunits. These interactions position STON2 as a bridge between cargo proteins and the vesicle formation machinery. Employing a STON2 antibody enables the investigation of how this adaptor protein regulates cargo selection and vesicle budding in both neuronal and non-neuronal systems.

Disruption of STON2 function has been linked to neurological and psychiatric conditions, as defects in synaptic vesicle recycling can impair neurotransmission. In addition, STON2 has been implicated in receptor internalization pathways outside the nervous system, suggesting broader roles in endocytic regulation. Studying STON2 with a STON2 antibody provides valuable insights into how defects in endocytosis contribute to disease mechanisms and may highlight potential therapeutic targets.

NSJ Bioreagents provides a high-quality STON2 antibody validated for applications including western blot, immunohistochemistry, and immunofluorescence. Choosing a STON2 antibody from NSJ Bioreagents ensures reliable performance and reproducibility in studies of clathrin-mediated endocytosis, synaptic biology, and receptor regulation.

UniProt: Q8WXE9