JMJD5 Antikörper (AA 4-406)

Produktnummer ABIN7874677

Der Kaninchen Polyklonal anti-JMJD5 Antikörper (ABIN7874677) detektiert spezifisch JMJD5 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für JMJD5 Antikörper (AA 4-406) (ABIN7874677)

Target: JMJD5 (Jumonji Domain Containing 5 (JMJD5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JMJD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-JMJD5 Antikörper

Bindungsspezifität: AA 4-406

Verwendungszweck: KDM8 Antibody / Lysine-specific demethylase 8

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human KDM8 recombinant protein (Position: D4-D406) was used as the immunogen for the KDM8 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the KDM8 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the KDM8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu JMJD5

Target: JMJD5 (Jumonji Domain Containing 5 (JMJD5))

Andere Bezeichnung: KDM8

Hintergrund: KDM8 antibody detects Lysine-specific demethylase 8, a histone demethylase that regulates chromatin organization, transcription, and cell cycle progression. Encoded by the KDM8 gene on chromosome 16p12.1, this enzyme demethylates dimethylated lysine 36 on histone H3 (H3K36me2), a modification associated with transcriptional elongation and gene regulation. KDM8 plays an essential role in epigenetic control of gene expression, particularly during mitotic progression and differentiation.

KDM8, also known as JMJD5, is a member of the Jumonji C (JmjC) domain-containing family of Fe(II)- and 2-oxoglutarate-dependent oxygenases. It localizes to the nucleus and functions both as a histone demethylase and as a cofactor for cell cycle regulatory proteins such as CDK1. Through these activities, KDM8 coordinates chromatin dynamics and ensures proper metaphase alignment during mitosis.

The KDM8 antibody is widely used in epigenetics, developmental biology, and cancer research to study histone methylation control, transcriptional regulation, and chromatin remodeling. Western blot analysis detects a 47 kilodalton band corresponding to KDM8, while immunofluorescence reveals nuclear staining consistent with its chromatin-associated functions. This antibody enables examination of histone modification patterns and their effects on gene expression and cell division.

Aberrant expression of KDM8 has been linked to oncogenesis, particularly in breast and prostate cancers, where it promotes proliferation and cell cycle progression by modulating chromatin accessibility. KDM8 also interacts with p53 and ribosomal proteins to coordinate metabolic and stress responses. The KDM8 antibody provides a powerful tool for studying epigenetic regulation and transcriptional dynamics. NSJ Bioreagents offers this antibody validated for its applications, ensuring accurate detection in chromatin and gene regulation research.

UniProt: Q8N371

Pathways: Chromatin Binding