BRD1 Antikörper (AA 395-913)

Produktnummer ABIN7874640

Der Kaninchen Polyklonal anti-BRD1 Antikörper wird verwendet zum Nachweis von BRD1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, ICC, FACS und IF.

Kurzübersicht für BRD1 Antikörper (AA 395-913) (ABIN7874640)

Target: BRD1 (Bromodomain Containing 1 (BRD1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-BRD1 Antikörper

Bindungsspezifität: AA 395-913

Verwendungszweck: BRD1 Antibody / Bromodomain-containing protein 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human BRD1 recombinant protein (Position: R395-Q913) was used as the immunogen for the BRD1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the BRD1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the BRD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu BRD1

Target: BRD1 (Bromodomain Containing 1 (BRD1))

Andere Bezeichnung: BRD1

Hintergrund: BRD1 antibody detects Bromodomain-containing protein 1, encoded by the BRD1 gene on chromosome 22q13.33. BRD1 antibody is widely used in epigenetics, transcription regulation, and psychiatric disorder research. BRD1 is a chromatin-associated protein that functions as part of histone acetyltransferase complexes, including HBO1 and MOZ/MORF, which regulate transcriptional activation. It contributes to histone acetylation at gene promoters, influencing chromatin accessibility and gene expression. BRD1 plays key roles in neuronal development, hematopoiesis, and immune responses.

Structurally, BRD1 is a ~120 kDa nuclear protein that contains a bromodomain for acetyl-lysine recognition, a PHD finger, and other protein interaction motifs. These domains enable BRD1 to interact with histone tails, transcription factors, and co-activators. Alternative splicing generates multiple isoforms that may provide tissue-specific functions. BRD1 predominantly localizes to chromatin-rich nuclear compartments.

Functionally, BRD1 acts as a scaffold and chromatin reader, recruiting histone acetyltransferases to target promoters. It regulates genes involved in neurodevelopment, immune signaling, and cell cycle control. Knockdown of BRD1 disrupts neuronal differentiation and immune cell function, emphasizing its developmental roles. Researchers use BRD1 antibody to investigate chromatin remodeling, histone modifications, and transcriptional control.

Clinically, BRD1 has been linked to neuropsychiatric disorders, including schizophrenia and bipolar disorder. Genetic variants near BRD1 influence risk of mental illness, possibly by altering chromatin regulation during brain development. Dysregulation of BRD1 has also been reported in cancer, where it contributes to abnormal gene expression programs. NSJ Bioreagents provides BRD1 antibody for studies of chromatin biology, neuroscience, and oncology.

Experimentally, BRD1 antibody is used in western blotting to detect the ~120 kDa protein, in chromatin immunoprecipitation (ChIP) to study histone acetylation complexes, and in immunohistochemistry to analyze tissue distribution. Co-immunoprecipitation with BRD1 antibody identifies interactions with histone acetyltransferases and transcriptional regulators.

UniProt: O95696