TRIM39 Antikörper (AA 37-490)

Produktnummer ABIN7874406

Der Kaninchen Polyklonal anti-TRIM39 Antikörper wird verwendet zum Nachweis von TRIM39 in Proben von Human. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für TRIM39 Antikörper (AA 37-490) (ABIN7874406)

Target: TRIM39 (Tripartite Motif Containing 39 (TRIM39))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM39 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-TRIM39 Antikörper

Bindungsspezifität: AA 37-490

Verwendungszweck: TRIM39 Antibody / Tripartite motif-containing protein 39

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human TRIM39 recombinant protein (Position: K37-K490) was used as the immunogen for the TRIM39 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TRIM39 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TRIM39 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu TRIM39

Target: TRIM39 (Tripartite Motif Containing 39 (TRIM39))

Andere Bezeichnung: TRIM39

Hintergrund: TRIM39 antibody recognizes Tripartite motif-containing protein 39, an E3 ubiquitin-protein ligase that controls apoptosis, immune responses, and cell cycle progression. TRIM39 belongs to the tripartite motif family, which features a RING finger, one or two B-box motifs, and a coiled-coil domain responsible for self-association and substrate targeting. The TRIM39 antibody is used to study ubiquitin-mediated protein degradation, antiviral immunity, and oncogenic signaling events regulated by selective ubiquitination.

TRIM39 is encoded by the TRIM39 gene on human chromosome 6p22.1. The protein localizes to both cytoplasmic and nuclear compartments and serves as a negative regulator of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase critical for mitotic progression. Through this inhibition, TRIM39 stabilizes APC/C substrates and contributes to cell cycle control. It also mediates ubiquitination of transcription factors such as NFATc3 and c-Jun, thereby influencing apoptosis and immune signaling. TRIM39 expression is tightly regulated during stress, infection, and DNA damage.

Western blot using the TRIM39 antibody typically reveals an ~60 kilodalton band. Immunofluorescence demonstrates punctate cytoplasmic staining consistent with TRIM family bodies involved in ubiquitin signaling. Functional assays show that TRIM39 enhances cell proliferation by targeting pro-apoptotic proteins for degradation but can also promote cell death under specific conditions, highlighting its dual regulatory nature. In cancer, TRIM39 overexpression has been observed in colorectal and hepatic tumors, where it modulates p53 activity and supports cell survival. In contrast, downregulation impairs growth and increases sensitivity to stress-induced apoptosis.

TRIM39 also plays roles in antiviral responses, acting as a modulator of type I interferon signaling. By ubiquitinating immune regulators, it fine-tunes cytokine production and antiviral defense. Beyond its role in signaling, TRIM39 may interact with chromatin-associated proteins, influencing gene transcription and epigenetic regulation. NSJ Bioreagents offers a validated TRIM39 antibody optimized for western blot, immunoprecipitation, and immunofluorescence applications. This antibody provides researchers with a reliable reagent for investigating ubiquitin-dependent signaling, apoptosis, and immune control.

UniProt: Q9HCM9