Factor VII Antikörper (AA 366-466)

Produktnummer ABIN7874359

Der Maus Monoklonal anti-Factor VII Antikörper (Klon F7-3512) (ABIN7874359) detektiert spezifisch Factor VII in ELISA und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Factor VII Antikörper (AA 366-466) (ABIN7874359)

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Factor VII Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: F7-3512

Produktdetails anti-Factor VII Antikörper

Bindungsspezifität: AA 366-466

Verwendungszweck: Coagulation Factor VII Antibody / F7

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 366-466) from the human protein was used as the immunogen for the Coagulation Factor VII antibody.

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Coagulation Factor VII antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Coagulation Factor VII antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Factor VII

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Andere Bezeichnung: Coagulation Factor VII

Hintergrund: Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.

UniProt: P08709

Pathways: Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling