TTLL9 Antikörper (AA 36-439)

Produktnummer ABIN7874319

Der Kaninchen Polyklonal anti-TTLL9 Antikörper wird verwendet zum Nachweis von TTLL9 in Proben von Human, Maus und Ratte. Er wurde validiert für ELISA und WB.

Kurzübersicht für TTLL9 Antikörper (AA 36-439) (ABIN7874319)

Target: TTLL9 (Tubulin tyrosine Ligase-Like Family, Member 9 (TTLL9))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TTLL9 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-TTLL9 Antikörper

Bindungsspezifität: AA 36-439

Verwendungszweck: TTLL9 Antibody / Tubulin tyrosine ligase-like protein 9

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human TTLL9 recombinant protein (Position: K36-S439) was used as the immunogen for the TTLL9 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TTLL9 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TTLL9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu TTLL9

Target: TTLL9 (Tubulin tyrosine Ligase-Like Family, Member 9 (TTLL9))

Andere Bezeichnung: TTLL9

Hintergrund: TTLL9 antibody detects Tubulin tyrosine ligase-like protein 9, encoded by the TTLL9 gene. Tubulin tyrosine ligase-like protein 9 is a member of the tubulin tyrosine ligase-like family of enzymes and is involved in post-translational modification of tubulin through polyglutamylation. TTLL9 antibody provides researchers with a reagent for studying microtubule regulation, ciliary function, and neuronal biology.

Tubulin tyrosine ligase-like protein 9 belongs to a large family of enzymes that regulate tubulin side chain modifications. Research using TTLL9 antibody has shown that it catalyzes polyglutamylation of tubulin tails, a modification that regulates microtubule interactions with molecular motors and associated proteins. This modification is essential for the structural and functional diversity of the microtubule cytoskeleton.

Studies with TTLL9 antibody have demonstrated that polyglutamylation mediated by TTLL9 is critical for ciliary function and neuronal signaling. In cilia, TTLL9 activity regulates motility and sensory reception, while in neurons, it influences axonal transport and synaptic function. These findings underscore its broad importance in cellular physiology.

Dysfunction of Tubulin tyrosine ligase-like protein 9 has been linked to ciliopathies and neurological disease. Research using TTLL9 antibody has shown that defects in polyglutamylation cause impaired ciliary motility, sensory dysfunction, and neurodegeneration. In addition, altered TTLL9 activity has been observed in certain cancers, suggesting roles in proliferation and cytoskeletal regulation.

TTLL9 antibody is widely applied in immunofluorescence, western blotting, and immunohistochemistry. Immunofluorescence highlights modified microtubule arrays, western blotting quantifies expression across tissues, and immunohistochemistry demonstrates localization in brain and ciliated tissues. These applications make TTLL9 antibody indispensable in microtubule research.

By supplying validated TTLL9 antibody reagents, NSJ Bioreagents supports studies into tubulin modification, neuronal function, and ciliary biology. Detection of Tubulin tyrosine ligase-like protein 9 provides researchers with insight into how post-translational modification regulates microtubule diversity and disease.

UniProt: Q3SXZ7