SMAD7 Antikörper (AA 353-388)

Produktnummer ABIN7874259

Der Kaninchen Polyklonal anti-SMAD7 Antikörper wird verwendet zum Nachweis von SMAD7 in Proben von Human. Er wurde validiert für WB und ELISA.

Kurzübersicht für SMAD7 Antikörper (AA 353-388) (ABIN7874259)

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SMAD7 Antikörper

Bindungsspezifität: AA 353-388

Verwendungszweck: SMAD7 Antibody / MADH7

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R353-Q388) was used as the immunogen for the SMAD7 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SMAD7 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SMAD7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SMAD7

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Andere Bezeichnung: SMAD7

Hintergrund: Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

UniProt: O15105

Pathways: Interferon-gamma Pathway, Cell-Cell Junction Organization