KRT14 Antikörper (AA 350-472)

Produktnummer ABIN7874217

Der Maus Monoklonal anti-KRT14 Antikörper wird verwendet zum Nachweis von KRT14 in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für KRT14 Antikörper (AA 350-472) (ABIN7874217)

Target: KRT14 (Keratin 14 (KRT14))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KRT14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: KRT14-4128

Produktdetails anti-KRT14 Antikörper

Bindungsspezifität: AA 350-472

Verwendungszweck: KRT14 Antibody / Cytokeratin 14 / CK14 (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 350-472 was used as the immunogen for the KRT14 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the KRT14 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the KRT14 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu KRT14

Target: KRT14 (Keratin 14 (KRT14))

Andere Bezeichnung: KRT14

Hintergrund: Cytokeratin 14 is a member of the type I keratin family of intermediate filament proteins. It always pairs with the type II keratin K5 and form the primary keratin pair of the keratinocytes of stratified squamous epithelia, including the epidermis as well as mucosal non-keratinizing stratified squamous epithelia. Cytokeratin 14 is strongly expressed in the undifferentiated basal cell layer containing the stem cells and are down-regulated in the differentiating suprabasal cell layers. Otherwise, in the widely well stratified follicular outer root sheath, cytokeratin 14 is uniformly expressed throughout all layers. The expression spectrum of cytokeratin 14 in tumors corresponds well to the patterns in normal epithelia. Thus, most squamous cell carcinomas as well as malignant mesotheliomas strongly express this keratin whereas little, focal, or no expression is found in adenocarcinomas. Cytokeratin 14 may be a useful marker in the differential diagnosis of squamous cell carcinoma from other epithelial tumors. Recent studies also indicate that CK14 expression in breast cancer corresponded with poor clinical outcome and that CK14 may have diagnostic value in the sub-classification of NSCLC.

UniProt: P02533