RNLS Antikörper (AA 34-235)

Produktnummer ABIN7874066

Dieser Maus Monoklonal Antikörper detektiert spezifisch RNLS in ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für RNLS Antikörper (AA 34-235) (ABIN7874066)

Target: RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RNLS Antikörper ist unkonjugiert

Applikation: ELISA

Güteklasse: Carrier-free

Klon: RNLS-1940

Produktdetails anti-RNLS Antikörper

Bindungsspezifität: AA 34-235

Verwendungszweck: Renalase Antibody (azide and preservative free)

Aufreinigung: Protein G affinity

Immunogen: A portion of amino acids 34-235 from the human protein was used as the immunogen for the Renalase antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Renalase antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Renalase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu RNLS

Target: RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

Andere Bezeichnung: Renalase

Hintergrund: Renalase is a 342 amino acid FAD-dependent amine oxidase that is highly expressed in kidney and is expressed at a lower level in heart, skeletal muscle and small intestine. Renalase is secreted in the blood by the kidney and it is thought to regulate cardiac function and systemic blood pressure. It is also suggested that Renalase functions as a hormone that metabolizes circulating catecholamines, which have an active role in the sympathetic and parasympathetic nervous systems. Individuals with chronic kidney disease and end-stage renal disease have markedly reduced levels of plasma Renalase than healthy individuals. Infusion of Renalase in animal models causes decrease in heart rate, cardiac contractility and blood pressure. Two isoforms of Renalase exist due to alternative splicing events.

UniProt: Q5VYX0