PGS1 Antikörper (AA 33-525)

Produktnummer ABIN7874005

Der Kaninchen Polyklonal anti-PGS1 Antikörper (ABIN7874005) detektiert spezifisch PGS1 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Ratte.

Kurzübersicht für PGS1 Antikörper (AA 33-525) (ABIN7874005)

Target: PGS1 (Phosphatidylglycerophosphate Synthase 1 (PGS1))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PGS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-PGS1 Antikörper

Bindungsspezifität: AA 33-525

Verwendungszweck: PGS1 Antibody / Phosphatidylglycerophosphate synthase 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human PGS1 recombinant protein (Position: R33-R525) was used as the immunogen for the PGS1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PGS1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PGS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PGS1

Target: PGS1 (Phosphatidylglycerophosphate Synthase 1 (PGS1))

Andere Bezeichnung: PGS1

Hintergrund: PGS1 antibody detects Phosphatidylglycerophosphate synthase 1, encoded by the PGS1 gene on chromosome 17q21.33. PGS1 antibody is widely used in studies of mitochondrial lipid metabolism, cardiolipin biosynthesis, and cellular energy homeostasis. PGS1 encodes a key enzyme in the biosynthetic pathway for phosphatidylglycerophosphate, which is a precursor of phosphatidylglycerol and cardiolipin. These mitochondrial phospholipids are essential for respiratory chain function, mitochondrial morphology, and apoptosis regulation.

Structurally, PGS1 is a ~56 kDa protein localized to the inner mitochondrial membrane. It contains transmembrane domains that anchor it within the lipid bilayer and a catalytic region that mediates condensation of CDP-diacylglycerol with glycerol-3-phosphate. The enzyme operates as part of the mitochondrial lipid biosynthesis machinery, which coordinates the synthesis of cardiolipin required for respiratory chain supercomplex stability.

Functionally, PGS1 generates phosphatidylglycerophosphate, which is dephosphorylated to phosphatidylglycerol and further converted to cardiolipin. Cardiolipin is critical for optimal activity of electron transport chain complexes and mitochondrial dynamics. Disruption of PGS1 function impairs cardiolipin synthesis, leading to defective oxidative phosphorylation, altered mitochondrial morphology, and increased susceptibility to apoptosis. Researchers use PGS1 antibody to study lipid metabolism, mitochondrial function, and cell death pathways.

Clinically, mutations in PGS1 cause mitochondrial disorders characterized by lactic acidosis, developmental delay, and cardiomyopathy. PGS1 deficiency resembles Barth syndrome due to cardiolipin deficiency. Dysregulation of cardiolipin metabolism has been linked to neurodegeneration, cancer, and metabolic diseases. Because cardiolipin plays a role in apoptosis signaling, PGS1 has also been investigated in cancer biology. NSJ Bioreagents supplies PGS1 antibody to support studies of mitochondrial disease, lipid biology, and energy metabolism.

Experimentally, PGS1 antibody is used in western blotting to detect the ~56 kDa protein, in immunohistochemistry to examine mitochondrial distribution in tissues, and in immunofluorescence microscopy to assess subcellular localization. Co-immunoprecipitation with PGS1 antibody identifies interactions with cardiolipin synthase and other lipid biosynthetic enzymes.

UniProt: Q32NB8