Claudin 18 Antikörper (AA 31-261)

Produktnummer ABIN7873758

Der Kaninchen Polyklonal anti-Claudin 18 Antikörper wird verwendet zum Nachweis von Claudin 18 in Proben von Human und Ratte. Er wurde validiert für WB, ELISA, FACS, IF und IHC (p).

Kurzübersicht für Claudin 18 Antikörper (AA 31-261) (ABIN7873758)

Target: Claudin 18 (CLDN18)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Claudin 18 Antikörper

Bindungsspezifität: AA 31-261

Verwendungszweck: Claudin 18 Antibody / CLDN18

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids S31-V261) was used as the immunogen for the Claudin 18 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Claudin 18 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Claudin 18 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Claudin 18

Target: Claudin 18 (CLDN18)

Andere Bezeichnung: Claudin 18

Hintergrund: Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

UniProt: P56856

Pathways: Cell-Cell Junction Organization, Hepatitis C