SUSD2 Antikörper (AA 301-593)

Produktnummer ABIN7873713

Der Kaninchen Polyklonal anti-SUSD2 Antikörper wird verwendet zum Nachweis von SUSD2 in Proben von Human. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für SUSD2 Antikörper (AA 301-593) (ABIN7873713)

Target: SUSD2 (Sushi Domain Containing 2 (SUSD2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUSD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-SUSD2 Antikörper

Bindungsspezifität: AA 301-593

Verwendungszweck: SUSD2 Antibody / Sushi domain-containing protein 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SUSD2 recombinant protein (Position: D301-H593) was used as the immunogen for the SUSD2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SUSD2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SUSD2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SUSD2

Target: SUSD2 (Sushi Domain Containing 2 (SUSD2))

Andere Bezeichnung: SUSD2

Hintergrund: SUSD2 antibody detects Sushi domain-containing protein 2, a type I transmembrane glycoprotein involved in cell adhesion, immune modulation, and tumor progression. The UniProt recommended name is Sushi domain-containing protein 2 (SUSD2). This protein contains multiple extracellular domains that mediate interactions with matrix components and immune receptors, influencing cell signaling and tissue organization.

Functionally, SUSD2 antibody identifies a 822-amino-acid membrane protein that includes somatomedin B, AMOP, von Willebrand factor type D, and Sushi (CCP) domains. These motifs facilitate cell-cell and cell-matrix adhesion while modulating immune recognition and tumor microenvironment interactions. SUSD2 supports epithelial integrity and participates in TGF-beta and Wnt signaling pathways that control cell differentiation and invasion.

The SUSD2 gene is located on chromosome 22q11.23 and is expressed in endothelial cells, epithelial tissues, and several cancer types. Its expression is elevated in breast, ovarian, and colorectal cancers, where it contributes to tumor growth, angiogenesis, and immune evasion. In normal physiology, SUSD2 is thought to support epithelial repair and maintain mucosal homeostasis.

Pathologically, overexpression of SUSD2 promotes tumor cell adhesion, migration, and immune suppression through interactions with Galectin-1 and other immunoregulatory factors. Conversely, in certain contexts, SUSD2 may enhance antitumor immune responses by facilitating macrophage activation. Research using SUSD2 antibody supports studies in cancer immunology, cell adhesion, and signal transduction.

SUSD2 antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect adhesion-related glycoproteins. NSJ Bioreagents provides SUSD2 antibody reagents optimized for oncology, immunology, and cell signaling research.

Structurally, Sushi domain-containing protein 2 features multiple modular domains connected by disulfide bonds, forming a flexible extracellular scaffold that mediates protein-protein interactions. The cytoplasmic tail contains potential phosphorylation sites that regulate receptor signaling and intracellular trafficking. This antibody enables investigation of SUSD2's functional role in adhesion, cancer progression, and immune modulation.

UniProt: Q9UGT4