Rekombinanter SOX11 Antikörper (AA 300-400)

Produktnummer ABIN7873608

Der Kaninchen Monoklonal anti-SOX11 Antikörper wird verwendet zum Nachweis von SOX11 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Rekombinanter SOX11 Antikörper (AA 300-400) (ABIN7873608)

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SOX11 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: SOX11-3235R

Produktdetails anti-SOX11 Antikörper

Bindungsspezifität: AA 300-400

Verwendungszweck: Recombinant SOX11 Antibody (azide and preservative free)

Aufreinigung: Protein A affinity chromatography

Immunogen: A portion of amino acids 300-400 from the human protein was used as the immunogen for the recombinant SOX11 antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant SOX11 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant SOX11 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu SOX11

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Andere Bezeichnung: SOX11

Hintergrund: Recognizes a protein of ~47 kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5 % to 10 % of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5 %-10 % of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.

UniProt: P35716

Pathways: Tube Formation