IVNS1ABP Antikörper (AA 30-580)

Produktnummer ABIN7873592

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch IVNS1ABP in WB, IHC, ELISA, IF, FACS und ICC. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für IVNS1ABP Antikörper (AA 30-580) (ABIN7873592)

Target: IVNS1ABP (Influenza Virus NS1A Binding Protein (IVNS1ABP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IVNS1ABP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Produktdetails anti-IVNS1ABP Antikörper

Bindungsspezifität: AA 30-580

Verwendungszweck: IVNS1ABP Antibody / Influenza virus NS1A-binding protein

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human IVNS1ABP recombinant protein (Position: Q30-D580) was used as the immunogen for the IVNS1ABP antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IVNS1ABP antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the IVNS1ABP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu IVNS1ABP

Target: IVNS1ABP (Influenza Virus NS1A Binding Protein (IVNS1ABP))

Andere Bezeichnung: IVNS1ABP

Substanzklasse: Influenza Protein

Hintergrund: IVNS1ABP antibody detects Influenza virus NS1A-binding protein, a multifunctional nuclear protein involved in RNA processing, chromatin remodeling, and stress responses. IVNS1ABP interacts with the influenza virus NS1A protein, modulating viral replication, but also has critical host cellular functions in normal physiology. It associates with transcriptional and splicing machinery, influences ribonucleoprotein complex assembly, and regulates cell growth and differentiation. The IVNS1ABP antibody is widely employed in studies of host-virus interactions, RNA metabolism, and nuclear architecture.

IVNS1ABP is encoded by the IVNS1ABP gene on human chromosome 1p13.3 and produces a protein of approximately 72 kDa. The protein contains multiple WD40 repeats that mediate protein-protein interactions and a nuclear localization signal that directs it to nucleoplasmic and speckle regions. IVNS1ABP interacts with heterogeneous nuclear ribonucleoproteins (hnRNPs), transcriptional regulators, and chromatin remodelers such as BRG1. Its diverse set of interactions positions it as a hub protein coordinating mRNA maturation and transport.

Research using the IVNS1ABP antibody shows that it contributes to the regulation of pre-mRNA splicing, ribosome biogenesis, and stress granule dynamics. Upon viral infection, IVNS1ABP binds to influenza NS1A protein, enhancing viral mRNA processing and nuclear export. However, under normal conditions, it supports cell survival and proliferation through stabilization of specific RNA-protein complexes. Western blot analysis typically identifies a band near 90 kDa, while immunofluorescence reveals nuclear and nucleolar staining. Loss of IVNS1ABP disrupts splicing patterns and increases sensitivity to stress-induced apoptosis.

Beyond viral interactions, IVNS1ABP is linked to cell differentiation and cytoskeletal organization. It modulates actin dynamics by interacting with profilin and other actin-binding proteins, connecting nuclear signaling with cytoplasmic architecture. Dysregulation of IVNS1ABP has been implicated in developmental disorders and certain cancers. NSJ Bioreagents provides a validated IVNS1ABP antibody optimized for western blot, immunofluorescence, and co-immunoprecipitation applications. This reagent enables researchers to explore RNA processing, host-pathogen interactions, and transcriptional control mediated by this multifunctional nuclear protein.

UniProt: Q9Y6Y0

Pathways: Negative Regulation of intrinsic apoptotic Signaling