RILPL1 Antikörper (AA 3-324)

Produktnummer ABIN7873534

Der Kaninchen Polyklonal anti-RILPL1 Antikörper (ABIN7873534) detektiert spezifisch RILPL1 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Ratte.

Kurzübersicht für RILPL1 Antikörper (AA 3-324) (ABIN7873534)

Target: RILPL1 (Rab Interacting Lysosomal Protein-Like 1 (RILPL1))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RILPL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-RILPL1 Antikörper

Bindungsspezifität: AA 3-324

Verwendungszweck: RILPL1 Antibody / Rab interacting lysosomal protein like 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human RILPL1 recombinant protein (Position: E3-K324) was used as the immunogen for the RILPL1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the RILPL1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the RILPL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu RILPL1

Target: RILPL1 (Rab Interacting Lysosomal Protein-Like 1 (RILPL1))

Andere Bezeichnung: RILPL1

Hintergrund: RILPL1 antibody detects Rab interacting lysosomal protein like 1, encoded by the RILPL1 gene. Rab interacting lysosomal protein like 1 is a cytoplasmic protein associated with endosomal and lysosomal trafficking pathways and contributes to cellular transport processes. RILPL1 antibody provides researchers with a specific reagent for studying vesicle transport, Rab protein signaling, and lysosomal dynamics.

Rab interacting lysosomal protein like 1 belongs to a small family of proteins that interact with Rab GTPases. Research using RILPL1 antibody has shown that it participates in Rab8 and Rab10 mediated trafficking, regulating transport between recycling endosomes and lysosomes. This activity ensures accurate sorting of proteins and maintenance of membrane compartments. By stabilizing Rab interactions, RILPL1 promotes directional transport required for cell polarity and homeostasis.

Studies with RILPL1 antibody have demonstrated roles in neuronal cells. Rab interacting lysosomal protein like 1 regulates ciliogenesis and dendritic transport, contributing to neuronal morphology and signaling. Defects in RILPL1 expression have been associated with impaired ciliogenesis, which is linked to developmental disorders and neurodegeneration. These findings highlight its importance in specialized trafficking pathways of neurons.

In disease contexts, RILPL1 has been implicated in Parkinson disease. Research using RILPL1 antibody has shown that it interacts with LRRK2, a kinase mutated in familial Parkinson disease. Phosphorylation of Rab proteins by LRRK2 alters RILPL1 mediated trafficking, leading to lysosomal stress and defective autophagy. This suggests that RILPL1 is an important mediator of neurodegenerative pathology through its interaction with disease-associated signaling pathways.

RILPL1 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies protein levels and detects post-translational changes, immunohistochemistry reveals tissue-specific expression, and immunofluorescence demonstrates subcellular localization to vesicular compartments. These methods make RILPL1 antibody valuable in cell biology and neuroscience research.

By providing validated RILPL1 antibody reagents, NSJ Bioreagents supports studies into Rab signaling, vesicle trafficking, and neurodegeneration. Detection of Rab interacting lysosomal protein like 1 provides researchers with insights into how vesicular transport pathways influence development and disease.

UniProt: Q5EBL4