SRR Antikörper (AA 3-283)

Produktnummer ABIN7873531

Der Kaninchen Polyklonal anti-SRR Antikörper (ABIN7873531) detektiert spezifisch SRR in WB, IHC, ELISA, FACS, IF, IP und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für SRR Antikörper (AA 3-283) (ABIN7873531)

Target: SRR (Serine Racemase (SRR))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Produktdetails anti-SRR Antikörper

Bindungsspezifität: AA 3-283

Verwendungszweck: Serine racemase Antibody / SRR

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human Serine racemase/SRR recombinant protein (Position: A3-E283) was used as the immunogen for the Serine racemase antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Serine racemase antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Serine racemase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SRR

Target: SRR (Serine Racemase (SRR))

Andere Bezeichnung: Serine racemase

Hintergrund: Serine racemase antibody detects Serine racemase, encoded by the SRR gene on chromosome 17p13.3. Serine racemase antibody is widely used in research on amino acid metabolism, neurotransmission, and neurodegeneration. Serine racemase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the conversion of L-serine to D-serine, a co-agonist of NMDA receptors. This enzyme plays a central role in modulating glutamatergic neurotransmission and synaptic plasticity in the brain.

Structurally, Serine racemase is a ~37 kDa cytosolic protein containing a PLP-binding site and catalytic lysine essential for racemization activity. It forms homodimers, which stabilize enzymatic activity. In addition to racemization, Serine racemase can catalyze beta-elimination of water from serine to generate pyruvate, linking it to energy metabolism. Isoforms generated by alternative splicing display altered enzymatic properties.

Functionally, Serine racemase regulates D-serine availability, which acts at NMDA receptor glycine-binding sites to facilitate excitatory neurotransmission. This regulation influences synaptic plasticity, learning, and memory. Knockout studies demonstrate that loss of Serine racemase reduces D-serine levels, impairing NMDA receptor function. Researchers use Serine racemase antibody to study glutamatergic signaling, synaptic physiology, and neuropsychiatric disease.

Clinically, Serine racemase is implicated in schizophrenia, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and other neurological disorders. Reduced D-serine levels contribute to NMDA receptor hypofunction in schizophrenia, while elevated levels may cause excitotoxicity in ALS. Pharmacological modulation of Serine racemase activity is under investigation for treating these conditions. NSJ Bioreagents provides Serine racemase antibody for research in neurobiology, neurotransmission, and neurodegeneration.

Experimentally, Serine racemase antibody is used in western blotting to detect the ~37 kDa protein, in immunofluorescence microscopy to examine neuronal localization, and in immunohistochemistry to study brain distribution. Co-immunoprecipitation with Serine racemase antibody identifies interacting proteins such as GRIP and Golga3.

UniProt: Q9GZT4