Occludin Antikörper (AA 282-415)

Produktnummer ABIN7873295

Dieser Maus Monoklonal Antikörper detektiert spezifisch Occludin in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Occludin Antikörper (AA 282-415) (ABIN7873295)

Target: Occludin (OCLN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Occludin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: OCLN-2183

Produktdetails anti-Occludin Antikörper

Bindungsspezifität: AA 282-415

Verwendungszweck: Occludin Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 282-415) was used as the immunogen for the Occludin antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Occludin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Occludin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Occludin

Target: Occludin (OCLN)

Andere Bezeichnung: Occludin

Hintergrund: Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue, in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial Occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction.

UniProt: Q16625

Pathways: Cell-Cell Junction Organization, Hepatitis C