SSX2IP Antikörper (AA 27-614)

Produktnummer ABIN7873138

Der Kaninchen Polyklonal anti-SSX2IP Antikörper (ABIN7873138) detektiert spezifisch SSX2IP in WB, IHC, ELISA und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Ratte.

Kurzübersicht für SSX2IP Antikörper (AA 27-614) (ABIN7873138)

Target: SSX2IP (Synovial Sarcoma, X Breakpoint 2 Interacting Protein (SSX2IP))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSX2IP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Produktdetails anti-SSX2IP Antikörper

Bindungsspezifität: AA 27-614

Verwendungszweck: SSX2IP Antibody / SSX2 interacting protein

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SSX2IP recombinant protein (Position: K27-P614) was used as the immunogen for the SSX2IP antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SSX2IP antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SSX2IP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SSX2IP

Target: SSX2IP (Synovial Sarcoma, X Breakpoint 2 Interacting Protein (SSX2IP))

Andere Bezeichnung: SSX2IP

Hintergrund: SSX2IP antibody detects SSX2 interacting protein, encoded by the SSX2IP gene. SSX2 interacting protein is a centrosomal and basal body protein that regulates spindle assembly, ciliogenesis, and cell division. SSX2IP antibody provides researchers with a specific reagent for studying centrosome biology, ciliary function, and cancer progression.

SSX2 interacting protein was originally identified as an interaction partner of the cancer testis antigen SSX2. Research using SSX2IP antibody has shown that it localizes to centrosomes and spindle poles during mitosis, where it stabilizes microtubule anchoring. It is also recruited to basal bodies, where it contributes to ciliogenesis and cilia maintenance. These dual localizations highlight its importance in both cell division and ciliary function.

Studies with SSX2IP antibody have demonstrated that depletion of SSX2IP causes spindle defects, impaired chromosome segregation, and abnormal ciliogenesis. In developmental contexts, SSX2IP is required for normal ciliary signaling and embryogenesis. Its role in centrosome anchoring underscores its fundamental role in cell biology.

Dysregulation of SSX2 interacting protein has been associated with cancer and ciliopathies. Research using SSX2IP antibody has shown that overexpression occurs in acute myeloid leukemia and gastrointestinal cancers, where it promotes proliferation and survival. Deficiency in SSX2IP has been linked to ciliary defects and developmental abnormalities, emphasizing its importance in health and disease.

SSX2IP antibody is widely used in immunofluorescence, immunohistochemistry, and western blotting. Immunofluorescence highlights centrosomal and basal body localization, immunohistochemistry demonstrates tumor expression, and western blotting quantifies levels across development and disease models. These applications make SSX2IP antibody indispensable in centrosome and cancer research.

By providing validated SSX2IP antibody reagents, NSJ Bioreagents supports studies into spindle regulation, ciliary biology, and oncogenesis. Detection of SSX2 interacting protein provides researchers with insight into how centrosomal proteins contribute to division and disease.

UniProt: Q9Y2D8