PDCD1LG2 Antikörper (AA 27-220)

Produktnummer ABIN7873096

Der Maus Monoklonal anti-PDCD1LG2 Antikörper (Klon PDL2-1850) (ABIN7873096) detektiert spezifisch PDCD1LG2 in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PDCD1LG2 Antikörper (AA 27-220) (ABIN7873096)

Target: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PDCD1LG2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Güteklasse: Carrier-free

Klon: PDL2-1850

Produktdetails anti-PDCD1LG2 Antikörper

Bindungsspezifität: AA 27-220

Verwendungszweck: PDL2 Antibody / Programmed death ligand 2 / CD273 (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant fragment of human PD-L2 protein within amino acids 27-220 was used as the immunogen for the PDL2 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PDL2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the PDL2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu PDCD1LG2

Target: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Andere Bezeichnung: PDL2

Hintergrund: Recognizes a protein of about 31 kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.