PFKFB4 Antikörper (AA 266-296)

Produktnummer ABIN7873049

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PFKFB4 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PFKFB4 Antikörper (AA 266-296) (ABIN7873049)

Target: PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PFKFB4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-PFKFB4 Antikörper

Bindungsspezifität: AA 266-296

Verwendungszweck: PFKFB4 Antibody / PFK/FBPase 4

Aufreinigung: Antigen affinity

Immunogen: A portion of amino acids 266-296 from the human protein was used as the immunogen for the PFKFB4 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the PFKFB4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot the PFKFB4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu PFKFB4

Target: PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))

Andere Bezeichnung: PFKFB4

Hintergrund: PFKFB4, also called 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, is a key enzyme involved in the regulation of cellular metabolism. It acts as a regulator of the glycolysis process, which is the breakdown of glucose into energy. This enzyme is crucial for maintaining the balance between energy production and storage within the cell. Research has shown that dysregulation of PFKFB4 can have profound effects on cellular metabolism and ultimately, overall health. For example, overexpression of PFKFB4 has been linked to increased glycolysis and cancer cell proliferation, making it a potential target for cancer therapy. On the other hand, decreased levels of PFKFB4 have been associated with metabolic disorders such as diabetes. One particularly intriguing aspect of PFKFB4 is its dual function as both a kinase and a phosphatase. This unique feature allows it to not only stimulate glycolysis but also inhibit the breakdown of fructose-2,6-biphosphate, a key activator of glycolysis. This dual role gives PFKFB4 a central position in the complex regulatory network of cellular metabolism.

UniProt: Q16877