Cyclin T1 Antikörper (AA 253-281)

Produktnummer ABIN7872934

Der Kaninchen Polyklonal anti-Cyclin T1 Antikörper (ABIN7872934) detektiert spezifisch Cyclin T1 in WB und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für Cyclin T1 Antikörper (AA 253-281) (ABIN7872934)

Target: Cyclin T1 (CCNT1)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin T1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-Cyclin T1 Antikörper

Bindungsspezifität: AA 253-281

Verwendungszweck: CCNT1 Antibody / Cyclin T1

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 253-281 from the human protein was used as the immunogen for the CCNT1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the CCNT1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the CCNT1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Cyclin T1

Target: Cyclin T1 (CCNT1)

Andere Bezeichnung: CCNT1

Hintergrund: CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.

UniProt: O60563