HDDC3 Antikörper (AA 25-179)

Produktnummer ABIN7872846

Der Kaninchen Polyklonal anti-HDDC3 Antikörper wird verwendet zum Nachweis von HDDC3 in Proben von Human und Maus. Er wurde validiert für WB und ELISA.

Kurzübersicht für HDDC3 Antikörper (AA 25-179) (ABIN7872846)

Target: HDDC3 (HD Domain Containing 3 (HDDC3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDDC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-HDDC3 Antikörper

Bindungsspezifität: AA 25-179

Verwendungszweck: HDDC3 Antibody / HD domain-containing protein 3

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human HDDC3 recombinant protein (Position: K25-I179) was used as the immunogen for the HDDC3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the HDDC3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the HDDC3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu HDDC3

Target: HDDC3 (HD Domain Containing 3 (HDDC3))

Andere Bezeichnung: HDDC3

Hintergrund: HDDC3 antibody detects HD domain-containing protein 3, a mitochondrial enzyme involved in NAD metabolism and stress-induced apoptosis regulation. The UniProt recommended name is HD domain-containing protein 3 (HDDC3). Also known as mitochondrial stress response protein MESH1, this enzyme exhibits NADPH phosphatase activity and modulates cellular redox state during stress adaptation.

Functionally, HDDC3 antibody identifies a 246-amino-acid protein localized to the mitochondrial matrix and cytoplasm. HDDC3 hydrolyzes NADPH to NADP+, regulating redox balance and reactive oxygen species production. It serves as a mammalian homolog of bacterial stringent response hydrolases, linking metabolic control to cell survival and autophagy.

The HDDC3 gene is located on chromosome 9q21.12 and is widely expressed, with highest levels in liver, kidney, and brain. Under oxidative or nutrient stress, HDDC3 modulates mitochondrial function, suppresses excessive NADPH accumulation, and contributes to redox homeostasis.

Pathologically, dysregulation of HDDC3 affects metabolic stress responses and apoptosis. Loss of function sensitizes cells to oxidative damage, while overexpression has been associated with tumor progression and altered NADPH signaling. Research using HDDC3 antibody supports studies in metabolism, mitochondrial dynamics, and cell death pathways.

HDDC3 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect NADPH-regulating enzymes. NSJ Bioreagents provides HDDC3 antibody reagents optimized for studies in mitochondrial metabolism, apoptosis, and redox biology.

Structurally, HD domain-containing protein 3 contains a conserved metal-dependent hydrolase domain that coordinates divalent cations for catalysis. This antibody enables analysis of HDDC3's enzymatic role in maintaining redox equilibrium and mitochondrial resilience.

UniProt: Q8N4P3