STRADB Antikörper (AA 24-411)

Produktnummer ABIN7872690

Der Kaninchen Polyklonal anti-STRADB Antikörper wird verwendet zum Nachweis von STRADB in Proben von Human. Er wurde validiert für WB, ELISA, IF und FACS.

Kurzübersicht für STRADB Antikörper (AA 24-411) (ABIN7872690)

Target: STRADB (STE20-Related Kinase Adaptor beta (STRADB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STRADB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-STRADB Antikörper

Bindungsspezifität: AA 24-411

Verwendungszweck: ILPIP Antibody / Als2Cr2

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E24-E411) was used as the immunogen for the ILPIP antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ILPIP antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the ILPIP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu STRADB

Target: STRADB (STE20-Related Kinase Adaptor beta (STRADB))

Andere Bezeichnung: ILPIP

Hintergrund: STE20-related kinase adapter protein beta, also called ILP-interacting protein (ILPIP) and Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein (Als2Cr2), is an enzyme that in humans is encoded by the STRADB gene. This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt: Q9C0K7

Pathways: AMPK Signaling