MEG3 Antikörper (AA 23-561)

Produktnummer ABIN7872547

Der Kaninchen Polyklonal anti-MEG3 Antikörper (ABIN7872547) detektiert spezifisch MEG3 in WB, ELISA, IHC (p) und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MEG3 Antikörper (AA 23-561) (ABIN7872547)

Target: MEG3 (FAM129B) (Family with Sequence Similarity 129, Member B (FAM129B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEG3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-MEG3 Antikörper

Bindungsspezifität: AA 23-561

Verwendungszweck: FAM129B Antibody / MINERVA / NIBAN2

Aufreinigung: Affinity purified

Immunogen: An E. coli-derived human protein (amino acids K23-K561) was used as the immunogen for the FAM129B antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the FAM129B antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the FAM129B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MEG3

Target: MEG3 (FAM129B) (Family with Sequence Similarity 129, Member B (FAM129B))

Andere Bezeichnung: FAM129B

Hintergrund: FAM129B/Niban-like protein 1 (family with sequence similarity 129, member B) belongs to a poorly characterized family of Niban proteins that also includes FAM129A/Niban and FAM129C/Niban-like protein 2. FAM129A/Niban is implicated in the ER stress response and is upregulated at the protein level in thyroid carcinoma. FAM129C/Niban-like protein 2 is preferentially expressed in B-cells and is one of five biomarkers upregulated in whole blood from patients with colorectal carcinoma. FAM129B is broadly expressed and has been shown to be a downstream target of B-Raf in melanoma cells. Though FAM129B does not appear to regulate cell growth and division, phosphorylation of FAM129B by B-Raf is essential for the invasive potential of melanoma and non-melanoma cell lines. Deletion of FAM129B in melanoma cells significantly impairs B-Raf/MEK/Erk-dependent invasion into the extracellular matrix.

UniProt: Q96TA1