GHRHR Antikörper (AA 23-407)

Produktnummer ABIN7872532

Der Kaninchen Polyklonal anti-GHRHR Antikörper (ABIN7872532) detektiert spezifisch GHRHR in WB, ELISA, IHC und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für GHRHR Antikörper (AA 23-407) (ABIN7872532)

Target: GHRHR (Growth Hormone Releasing Hormone Receptor (GHRHR))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GHRHR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-GHRHR Antikörper

Bindungsspezifität: AA 23-407

Verwendungszweck: GHRHR Antibody / Growth hormone releasing hormone receptor

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human GHRHR recombinant protein (Position: H23-K407) was used as the immunogen for the GHRHR antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GHRHR antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the GHRHR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu GHRHR

Target: GHRHR (Growth Hormone Releasing Hormone Receptor (GHRHR))

Andere Bezeichnung: GHRHR

Hintergrund: GHRHR antibody detects Growth hormone releasing hormone receptor, encoded by the GHRHR gene. Growth hormone releasing hormone receptor is a G protein-coupled receptor expressed in the anterior pituitary, where it mediates responses to growth hormone releasing hormone. GHRHR antibody provides researchers with a tool to study endocrine signaling, growth regulation, and disease mechanisms involving pituitary hormone production.

Growth hormone releasing hormone receptor activates adenylate cyclase and cAMP signaling pathways upon binding its ligand. Research using GHRHR antibody has shown that this activation stimulates growth hormone synthesis and secretion. Growth hormone then regulates somatic growth, metabolism, and tissue repair through downstream IGF-1 production. This axis is essential for normal growth and metabolic homeostasis.

Studies with GHRHR antibody have revealed that mutations in GHRHR cause isolated growth hormone deficiency. This condition is characterized by short stature, delayed growth, and impaired metabolic adaptation. Mutations that disrupt receptor folding, trafficking, or signaling result in insufficient growth hormone production, demonstrating the receptor's critical physiological role.

Beyond growth deficiency, dysregulation of GHRHR signaling contributes to endocrine disease and cancer. Research using GHRHR antibody has shown that receptor variants are expressed in tumors such as pituitary adenomas and certain carcinomas. Aberrant signaling through GHRHR promotes proliferation and survival, linking it to oncogenic pathways. These findings highlight GHRHR as both a diagnostic marker and a potential therapeutic target.

GHRHR antibody is widely used in immunohistochemistry, western blotting, and receptor binding assays. Immunohistochemistry highlights expression in pituitary tissue, western blotting quantifies receptor levels, and binding studies confirm functional activity. These applications make GHRHR antibody indispensable in endocrinology and oncology research.

By providing validated GHRHR antibody reagents, NSJ Bioreagents supports studies into pituitary signaling, growth hormone regulation, and disease. Detection of Growth hormone releasing hormone receptor provides researchers with insights into how endocrine pathways control growth and metabolism.

UniProt: Q02643

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Hormone Transport, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process