STK38L Antikörper (AA 23-370)

Produktnummer ABIN7872529

Der Kaninchen Polyklonal anti-STK38L Antikörper (ABIN7872529) detektiert spezifisch STK38L in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Zebrafisch (Danio rerio).

Kurzübersicht für STK38L Antikörper (AA 23-370) (ABIN7872529)

Target: STK38L (serine/threonine Kinase 38 Like (STK38L))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STK38L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-STK38L Antikörper

Bindungsspezifität: AA 23-370

Verwendungszweck: Zebrafish Ndr2 Antibody / Cyclops / Nodal-related 2 precursor

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Ndr2 recombinant protein (amino acids K23-R370) was used as the immunogen for the Zebrafish Ndr2 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Ndr2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Ndr2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu STK38L

Target: STK38L (serine/threonine Kinase 38 Like (STK38L))

Andere Bezeichnung: Ndr2

Hintergrund: Ndr2, also called Nodal related protein 2 and Cyclops, is a secreted signaling molecule that belongs to the transforming growth factor beta superfamily. In zebrafish, Ndr2 plays an essential role in early embryonic development, particularly in the formation of mesoderm and endoderm, and in the establishment of the embryonic body axes. It functions through the Nodal signaling pathway, which regulates gene expression patterns necessary for germ layer differentiation and left right asymmetry.

Zebrafish Ndr2 is closely related in function to the human NODAL protein. While it is not a direct one to one ortholog due to gene duplication events in zebrafish, Ndr2 and human NODAL share conserved domains and activate similar signaling cascades through type one and type two serine threonine kinase receptors and intracellular SMAD transcription factors. Both proteins are tightly regulated by extracellular antagonists such as Lefty and intracellular feedback loops.

In zebrafish embryos, Ndr2 is expressed during gastrulation and is critical for the induction of the organizer region and patterning of the mesendoderm. Disruption of Ndr2 results in severe developmental defects, including failure to form the embryonic axis and internal organs. Because of its functional conservation with human NODAL and its central role in vertebrate development, zebrafish Ndr2 is widely used as a model to study signaling pathways involved in embryogenesis, tissue specification, and congenital malformations.

UniProt: P87358