DERL1 Antikörper (AA 224-251)

Produktnummer ABIN7872381

Der Kaninchen Polyklonal anti-DERL1 Antikörper wird verwendet zum Nachweis von DERL1 in Proben von Human und Maus. Er wurde validiert für WB, IHC (p) und FACS.

Kurzübersicht für DERL1 Antikörper (AA 224-251) (ABIN7872381)

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DERL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-DERL1 Antikörper

Bindungsspezifität: AA 224-251

Verwendungszweck: Derlin 1 Antibody / DERL1

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 224-251 from the human protein was used as the immunogen for the Derlin 1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Derlin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Derlin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu DERL1

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Andere Bezeichnung: Derlin 1

Hintergrund: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling