LY6D Antikörper (AA 21-111)

Produktnummer ABIN7872120

Der Kaninchen Polyklonal anti-LY6D Antikörper wird verwendet zum Nachweis von LY6D in Proben von Human. Er wurde validiert für ELISA, WB und IHC.

Kurzübersicht für LY6D Antikörper (AA 21-111) (ABIN7872120)

Target: LY6D (Lymphocyte Antigen 6 Complex, Locus D (LY6D))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LY6D Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-LY6D Antikörper

Bindungsspezifität: AA 21-111

Verwendungszweck: LY6D Antibody / Lymphocyte antigen 6D

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human LY6D recombinant protein (Position: L21-L111) was used as the immunogen for the LY6D antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the LY6D antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the LY6D antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu LY6D

Target: LY6D (Lymphocyte Antigen 6 Complex, Locus D (LY6D))

Andere Bezeichnung: LY6D

Hintergrund: LY6D antibody detects Lymphocyte antigen 6D, encoded by the LY6D gene. Lymphocyte antigen 6D is a glycosylphosphatidylinositol-anchored cell surface protein of the LY6/uPAR family, expressed in epithelial cells and lymphoid precursors. LY6D antibody provides researchers with a specific reagent for studying epithelial differentiation, lymphoid specification, and cancer biology.

Lymphocyte antigen 6D belongs to a family of GPI-anchored proteins characterized by the LY6/uPAR domain. Research using LY6D antibody has shown that it is expressed in epithelial cells of skin and mucosa, where it contributes to barrier formation and differentiation. In the hematopoietic system, LY6D marks early B cell precursors and distinguishes B lineage commitment from alternative lymphoid fates.

Studies with LY6D antibody have revealed that LY6D serves as a robust marker of B cell development in both mice and humans. Expression of LY6D indicates initiation of the B cell program, allowing identification of common lymphoid progenitors committed to B lineage. This makes LY6D antibody an important tool for immunology research and flow cytometric analysis of hematopoiesis.

Dysregulation of Lymphocyte antigen 6D has been associated with cancer and immune disorders. Research using LY6D antibody has shown that it is overexpressed in squamous cell carcinomas of head, neck, and esophagus, where it promotes tumor growth and invasion. In addition, LY6D has been proposed as a diagnostic biomarker and potential therapeutic target in epithelial cancers. Its expression in immune precursors also makes it relevant in studies of immune reconstitution and leukemia.

LY6D antibody is widely applied in flow cytometry, immunohistochemistry, and western blotting. Flow cytometry identifies B lineage progenitors, immunohistochemistry highlights epithelial expression in normal and tumor tissues, and western blotting quantifies levels across developmental and disease states. These applications make LY6D antibody indispensable for immunology and cancer research.

By providing validated LY6D antibody reagents, NSJ Bioreagents supports studies into epithelial differentiation, B cell biology, and cancer. Detection of Lymphocyte antigen 6D provides researchers with insight into how cell surface antigens regulate immunity and tumor progression.

UniProt: Q14210