MYORG/KIAA1161 Antikörper (AA 207-611)

Produktnummer ABIN7872108

Der Kaninchen Polyklonal anti-MYORG/KIAA1161 Antikörper wird verwendet zum Nachweis von MYORG/KIAA1161 in Proben von Human, Maus und Ratte. Er wurde validiert für ELISA, WB und FACS.

Kurzübersicht für MYORG/KIAA1161 Antikörper (AA 207-611) (ABIN7872108)

Target: MYORG/KIAA1161 (MYORG) (Myogenesis Regulating Glycosidase (MYORG))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYORG/KIAA1161 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-MYORG/KIAA1161 Antikörper

Bindungsspezifität: AA 207-611

Verwendungszweck: MYORG Antibody / Myogenesis-regulating glycosidase

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human MYORG recombinant protein (Position: Q207-R611) was used as the immunogen for the MYORG antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MYORG antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the MYORG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MYORG/KIAA1161

Target: MYORG/KIAA1161 (MYORG) (Myogenesis Regulating Glycosidase (MYORG))

Andere Bezeichnung: MYORG

Hintergrund: MYORG antibody detects Myogenesis-regulating glycosidase, a lysosomal and endoplasmic reticulum-associated enzyme involved in protein processing and neurological function. The UniProt recommended name is Myogenesis-regulating glycosidase (MYORG). This glycosidase is highly conserved and plays a crucial role in the maintenance of glycoprotein homeostasis within neural tissues, particularly astrocytes.

Functionally, MYORG antibody identifies a 714-amino-acid glycosidase belonging to the glycosyl hydrolase family 31. MYORG hydrolyzes terminal sugar residues from oligosaccharides and glycoproteins, participating in lysosomal degradation and protein quality control. It is mainly localized to the endoplasmic reticulum and perinuclear regions, suggesting involvement in post-translational processing rather than extracellular digestion.

The MYORG gene is located on chromosome 9p13.1 and is highly expressed in brain and skeletal muscle. In the central nervous system, MYORG supports astrocyte differentiation and intercellular communication. It is co-regulated with genes controlling lysosomal activity, endoplasmic reticulum homeostasis, and metabolic signaling.

Pathologically, mutations in MYORG cause primary familial brain calcification (PFBC), a neurodegenerative disorder characterized by calcium deposits in basal ganglia and cerebellum. Deficiency in MYORG leads to altered glycosylation and impaired protein turnover in astrocytes. Research using MYORG antibody assists studies of glycoprotein metabolism, lysosomal function, and neurological disease mechanisms.

MYORG antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect intracellular glycosidases and neuronal processing enzymes. NSJ Bioreagents provides MYORG antibody reagents optimized for neuroscience, enzymology, and cellular metabolism research.

Structurally, Myogenesis-regulating glycosidase contains a catalytic domain typical of glycosyl hydrolases with conserved acid-base residues, and a C-terminal transmembrane region anchoring it to intracellular membranes. This antibody supports analysis of MYORG's biochemical function and contribution to neurodegenerative disorders.

UniProt: Q6NSJ0

Pathways: Skeletal Muscle Fiber Development