TGF-beta Antikörper (AA 200-390)

Produktnummer ABIN7871990

Dieser Maus Monoklonal Antikörper detektiert spezifisch TGF-beta in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TGF-beta Antikörper (AA 200-390) (ABIN7871990)

Target: TGF-beta (TGFb)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TGF-beta Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: TGFB-7240

Produktdetails anti-TGF-beta Antikörper

Bindungsspezifität: AA 200-390

Verwendungszweck: TGF beta Antibody / TGFB (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 200-390) from the human TGFB1 was used as the immunogen for the TGF beta antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TGF beta antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the TGF beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu TGF-beta

Target: TGF-beta (TGFb)

Andere Bezeichnung: TGF beta

Hintergrund: This mAb recognizes TGF beta 1, 2 and 3. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF beta 3 protein has approximately 80 % identity to the mature region of both TGF beta 1 and TGF beta 2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGF beta s inhibits the growth of epithelial cells and stimulate the growth of mesenchymal cells.

UniProt: P01137

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus