DDIT4 Antikörper (AA 20-49)

Produktnummer ABIN7871875

Der Kaninchen Polyklonal anti-DDIT4 Antikörper (ABIN7871875) detektiert spezifisch DDIT4 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für DDIT4 Antikörper (AA 20-49) (ABIN7871875)

Target: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDIT4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DDIT4 Antikörper

Bindungsspezifität: AA 20-49

Verwendungszweck: REDD-1 Antibody / DDIT4

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 20-49 from the human protein was used as the immunogen for the REDD-1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the REDD-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the REDD-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu DDIT4

Target: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Andere Bezeichnung: REDD-1

Hintergrund: REDD-1 is a novel transcriptional target of p53 induced following DNA damage. During embryogenesis, REDD-1 expression mirrors the tissue-specific pattern of the p53 family member p63, and TP63 null embryos show virtually no expression of REDD-1, which is restored in mouse embryo fibroblasts following p63 expression. In differentiating primary keratinocytes, TP63 and REDD-1 expression are coordinately downregulated, and ectopic expression of either gene inhibits in vitro differentiation. REDD1 appears to function in the regulation of reactive oxygen species (ROS), TP63 null fibroblasts have decreased ROS levels and reduced sensitivity to oxidative stress, which are both increased following ectopic expression of either TP63 or REDD-1. Thus, REDD-1 encodes a shared transcriptional target that implicates ROS in the p53-dependent DNA damage response and in p63-mediated regulation of epithelial differentiation.

UniProt: Q9NX09

Pathways: Neurotrophin Signalübertragung, Regulation of Carbohydrate Metabolic Process