SELT Antikörper (AA 20-195)

Produktnummer ABIN7871841

Der Kaninchen Polyklonal anti-SELT Antikörper wird verwendet zum Nachweis von SELT in Proben von Human, Maus und Ratte. Er wurde validiert für ELISA, FACS, WB, IF und IHC (p).

Kurzübersicht für SELT Antikörper (AA 20-195) (ABIN7871841)

Target: SELT (Selenoprotein T (SELT))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SELT Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SELT Antikörper

Bindungsspezifität: AA 20-195

Verwendungszweck: SELT Antibody / SELENOT

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids S20-S195) was used as the immunogen for the SELT antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SELT antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SELT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SELT

Target: SELT (Selenoprotein T (SELT))

Andere Bezeichnung: SELT

Hintergrund: This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Thioredoxin reductase-like selenoprotein T is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5.

UniProt: P62341

Pathways: Cell RedoxHomeostasis