Rekombinanter Periostin Antikörper (AA 193-326)

Produktnummer ABIN7871694

Der Maus Monoklonal anti-Periostin Antikörper wird verwendet zum Nachweis von Periostin in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Rekombinanter Periostin Antikörper (AA 193-326) (ABIN7871694)

Target: Periostin (POSTN)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Periostin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RPOSTN-8522

Produktdetails anti-Periostin Antikörper

Bindungsspezifität: AA 193-326

Verwendungszweck: Recombinant POSTN Antibody / Periostin

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 193-326) from the human protein was used as the immunogen for the recombinant POSTN antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant POSTN antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant POSTN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Periostin

Target: Periostin (POSTN)

Andere Bezeichnung: POSTN

Hintergrund: Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for AlphaVBeta3 and AlphaVBeta5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor Beta 1 (TGF Beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

UniProt: Q15063