OSCAR Antikörper (AA 19-282)

Produktnummer ABIN7871582

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch OSCAR in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für OSCAR Antikörper (AA 19-282) (ABIN7871582)

Target: OSCAR (Osteoclast Associated Receptor (OSCAR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OSCAR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-OSCAR Antikörper

Bindungsspezifität: AA 19-282

Verwendungszweck: OSCAR Antibody / Osteoclast-associated immunoglobulin-like receptor

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human OSCAR recombinant protein (Position: D19-V282) was used as the immunogen for the OSCAR antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the OSCAR antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the OSCAR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu OSCAR

Target: OSCAR (Osteoclast Associated Receptor (OSCAR))

Andere Bezeichnung: OSCAR

Hintergrund: OSCAR antibody detects Osteoclast-associated immunoglobulin-like receptor, a transmembrane receptor expressed in osteoclasts and myeloid immune cells. The UniProt recommended name is Osteoclast-associated immunoglobulin-like receptor (OSCAR). This receptor participates in osteoclast differentiation, bone resorption, and immune regulation by transducing activation signals through association with the Fc receptor gamma chain.

Functionally, OSCAR antibody identifies a 287-amino-acid protein containing two extracellular immunoglobulin-like domains and a short cytoplasmic tail. OSCAR acts as a costimulatory receptor on osteoclast precursors, promoting NFATc1 activation and osteoclastogenesis in response to RANKL and ITAM signaling. It also mediates immune cell activation, cytokine secretion, and antigen presentation in monocytes and dendritic cells.

The OSCAR gene is located on chromosome 19q13.4 and is primarily expressed in bone-resorbing osteoclasts, macrophages, and dendritic cells. Its activity links the immune and skeletal systems, contributing to bone remodeling and inflammation-associated bone loss.

Pathologically, elevated OSCAR expression has been observed in rheumatoid arthritis, osteoporosis, and periodontitis, where excessive osteoclast activation leads to bone degradation. Research using OSCAR antibody supports studies in bone metabolism, immune signaling, and inflammatory disease mechanisms.

OSCAR antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect immunoreceptors involved in osteoclast and immune cell function. NSJ Bioreagents provides OSCAR antibody reagents optimized for studies in bone biology, osteoimmunology, and receptor signaling.

Structurally, Osteoclast-associated immunoglobulin-like receptor contains extracellular Ig-like domains that interact with collagen and intracellular motifs that recruit signaling adapters via Fc receptor gamma chains. This antibody enables examination of OSCAR's role in osteoclast activation and immune crosstalk.

UniProt: Q8IYS5