RBBP6 Antikörper (AA 19-1581)

Produktnummer ABIN7871562

Der Kaninchen Polyklonal anti-RBBP6 Antikörper wird verwendet zum Nachweis von RBBP6 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC, IF, FACS und ICC.

Kurzübersicht für RBBP6 Antikörper (AA 19-1581) (ABIN7871562)

Target: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RBBP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Produktdetails anti-RBBP6 Antikörper

Bindungsspezifität: AA 19-1581

Verwendungszweck: RBBP6 Antibody / Retinoblastoma binding protein 6

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human RBBP6 recombinant protein (Position: F19-E1581) was used as the immunogen for the RBBP6 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the RBBP6 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the RBBP6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu RBBP6

Target: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Andere Bezeichnung: RBBP6

Hintergrund: RBBP6 antibody detects Retinoblastoma binding protein 6, encoded by the RBBP6 gene. Retinoblastoma binding protein 6 is a multifunctional nuclear protein involved in mRNA processing, ubiquitination, and cell cycle regulation. RBBP6 antibody provides researchers with a reagent for studying transcriptional regulation, apoptosis, and tumorigenesis.

Retinoblastoma binding protein 6 interacts with the tumor suppressor pRb and with p53, positioning it as a critical regulator of cell cycle and apoptosis. Research using RBBP6 antibody has shown that it functions as an E3 ubiquitin ligase, targeting p53 for degradation. This activity links RBBP6 to apoptosis regulation and tumor suppression. It also interacts with splicing factors, influencing mRNA maturation and gene expression control.

Studies with RBBP6 antibody have demonstrated that dysregulation of RBBP6 contributes to cancer development. Overexpression of Retinoblastoma binding protein 6 is associated with progression of cervical, breast, and colon cancers, where it promotes cell survival by reducing p53 stability. Conversely, depletion of RBBP6 enhances apoptosis and impairs proliferation, highlighting its importance in tumor cell biology.

In addition to cancer, RBBP6 plays roles in development and immune function. Research using RBBP6 antibody has shown that it contributes to embryogenesis, hematopoiesis, and regulation of inflammatory responses. Its broad functional spectrum reflects its diverse interaction partners in transcriptional and post-transcriptional regulation.

RBBP6 antibody is widely applied in western blotting, immunohistochemistry, and RNA immunoprecipitation. Western blotting detects expression across tissues, immunohistochemistry highlights nuclear expression in tumors, and RNA immunoprecipitation identifies mRNA targets associated with RBBP6 complexes. These applications make RBBP6 antibody valuable in transcription and cancer research.

By providing validated RBBP6 antibody reagents, NSJ Bioreagents supports studies into ubiquitination, transcriptional regulation, and disease. Detection of Retinoblastoma binding protein 6 provides researchers with insight into how nuclear proteins regulate gene expression and apoptosis.

UniProt: Q7Z6E9

Pathways: Regulatorische RNA Pathways